Semaglutide
Ozempic, Wegovy, Rybelsus. GLP-1 receptor agonist. Pharmacology, dosing, contraindications, cost, off-label use.
Peptide Encyclopedia
90+ profiles. Healing, growth, signaling, immune, cognitive, longevity peptides — all cited, all tiered.
Tirzepatide
Mounjaro, Zepbound. Dual GIP/GLP-1 receptor agonist. Pharmacology, dosing, cost, head-to-head with semaglutide.
Supplement Database
Mechanism, evidence tier, dosing, interactions. Honest verdicts — what works, what doesn't, what's marketing.
Lab Interpretation
Reference ranges in plain English. What HbA1c, fasting insulin, ApoB, hsCRP, ferritin, and the rest actually mean.
Khavinson Bioregulators
All 40 short peptides decoded. Tissue-specificity, evidence base, regulatory status, sourcing realities.
Glossary
Every acronym, every mechanism term, every protocol abbreviation — defined on first reference.
Metformin
The biguanide. T2D first-line and the TAME off-label longevity case. AMPK mechanism, dosing, B12 caveat, exercise trade-off.
Rapamycin
mTOR inhibitor. Intermittent dosing rationale, the immune trade-off, what longevity-medicine clinics actually prescribe.
Retatrutide
Triple agonist — GLP-1 + GIP + glucagon. Phase 3 readouts, the efficacy ceiling shift, what to watch.
Liraglutide
First-gen GLP-1 (Saxenda, Victoza). Daily dosing, lower efficacy vs. sema/tirz, where it still has a niche.
Orforglipron
Oral small-molecule GLP-1. Non-peptide chemistry, food-independent dosing, Phase 3 readouts.
CagriSema
Cagrilintide + semaglutide combo. Amylin co-agonism, REDEFINE trial outcomes, the additive efficacy case.
Berberine
"Nature's Ozempic" framing — honestly compared. AMPK mechanism, the real evidence, the GI side-effect reality.
Creatine
Beyond strength — the cognitive RCT data (vegetarians + sleep-deprived strongest), monohydrate dosing, the safety record.
Modafinil
Wakefulness agent. Mechanism uncertainty, on-label vs. off-label, abuse-liability data, drug interactions.
Melatonin
The OTC dose problem. Why 0.3–0.5 mg is physiologic, melatonin as chronobiotic vs. hypnotic, DSPS use case.
Biological Age Tests
DNA methylation clocks compared — Horvath, PhenoAge, GrimAge, DunedinPACE. What each measures, intervention-responsiveness.